Postmenopausal women with normal body mass index (BMI) but higher body fat levels at the same time may be at an increased risk of breast cancer, suggests new research.
BMI refers to the ratio of weight to height, but it is not an exact way to determine whole body fat levels, as muscle mass and bone density cannot be distinguished from fat mass.
The researchers found that the risk of breast cancer increased by 35 per cent for each five kilogram increase in whole body fat, despite having a normal BMI.
"Our findings show that the risk of invasive breast cancer is increased in postmenopausal women with normal BMI and higher levels of body fat, meaning that a large proportion of the population has an unrecognized risk of developing cancer," said Neil Iyengar, an oncologist at the Memorial Sloan Kettering Cancer Center in New York.
The findings of the research are scheduled to be presented at a conference of the American Association for Cancer Research to be held in Texas from January 27-30.
The study noted that the level of physical activity was lower in women with higher amounts of body fat, which further suggested the necessity of physical activity not only for the overweight people but also in those who are not obese.
For the study, the researchers analyzed data from the Women's Health Initiative (WHI), an observational study that follows the health of postmenopausal women aged 50-79.
During the median 16 years of follow-up, study participants were assessed for the development of invasive breast cancer, and cancer cases were evaluated for estrogen receptor (ER) positivity.
Of the 3,460 participants in the study, 182 developed invasive breast cancer during follow-up and 146 of these cases were ER-positive.
About 80 per cent of all breast cancers are believed to be ER-positive.
Analyzing the data, the researchers found a link between the risk of breast cancer and higher whole body fat even in women with normal BMI.